This creamy, flavorful Cajun Chicken Alfredo with Broccoli & Penne is a dinner winner that brings a spicy twist to a classic Italian favorite. Tender chicken breasts seasoned with aromatic Cajun spices, al dente penne pasta, and fresh broccoli florets all come together in a luscious Parmesan cream sauce that’s comforting yet packed with bold flavors. Whether you’re cooking for a weeknight family meal or looking to impress guests without fuss, this recipe is your go-to for a balanced, satisfying plate that’s both hearty and fresh.

Why It Deserves a Spot

This recipe earns its place in your repertoire because it strikes the perfect balance between indulgence and nutrition. The Cajun seasoning adds a smoky, spicy kick that wakes up the palate, transforming ordinary chicken into something extraordinary. The broccoli provides a fresh, crisp contrast and nutritional boost, while the creamy Alfredo sauce ties everything together with rich, velvety goodness. Plus, penne pasta is the ideal shape to hold onto every bit of sauce, making every bite luscious and flavorful.

What’s more, this dish is incredibly versatile and easy to prepare, making it suitable for busy weeknights or leisurely weekend dinners. If you like dishes that combine spice, creaminess, and a touch of green, this Cajun Chicken Alfredo with Broccoli & Penne is guaranteed to become a staple.

Gather These Ingredients

2 boneless, skinless chicken breasts – sliced or left whole depending on preference
2 tablespoons Cajun seasoning – a blend of paprika, cayenne, garlic powder, and herbs
8 ounces penne pasta – the perfect tube-shaped pasta to capture sauce
2 cups broccoli florets – fresh, bright, and lightly steamed
1 tablespoon olive oil – for searing the chicken
2 cloves garlic, minced – for a fragrant base to the sauce
1 cup heavy cream – creates that rich, silky Alfredo sauce
1 cup grated Parmesan cheese – adds sharp, nutty flavor
Salt and pepper to taste – to enhance all the flavors
Fresh parsley for garnish – brightens the dish with color and freshness

Equipment & Tools

Large pot – to boil the penne pasta
Large skillet or frying pan – for cooking the chicken and making the sauce
Colander – to drain the pasta and broccoli
Knife and cutting board – for chopping and slicing
Measuring spoons and cups – to get your seasonings and cream just right
Wooden spoon or silicone spatula – for stirring the sauce

Build Cajun Chicken Alfredo with Broccoli & Penne Step by Step

Step 1: Prepare and Season the Chicken

Pat the chicken breasts dry with paper towels. Sprinkle both sides generously with the Cajun seasoning, pressing it in for maximum flavor. This step ensures the chicken will develop a beautifully spiced crust when cooked.

Step 2: Boil Pasta and Steam Broccoli

Bring a large pot of salted water to a boil. Add the penne pasta and cook according to package directions until al dente, usually about 10-12 minutes. In the last 3 minutes of cooking, add the broccoli florets to the pot to blanch them until bright green and tender-crisp. Drain both pasta and broccoli together in a colander and set aside.

Step 3: Cook the Chicken

Heat the olive oil in a large skillet over medium-high heat. Add the seasoned chicken breasts and cook for about 5-6 minutes per side, or until fully cooked through and golden brown on the outside. Remove the chicken from the skillet and let it rest for a few minutes before slicing it into strips or bite-sized pieces.

Step 4: Make the Alfredo Sauce

In the same skillet, lower the heat to medium and add the minced garlic. Sauté for 1-2 minutes until fragrant but not browned. Pour in the heavy cream and bring it to a gentle simmer, stirring frequently. Gradually add the grated Parmesan cheese, stirring continuously until the sauce is smooth and thickened. Season with salt and pepper to taste.

Step 5: Combine Everything

Add the cooked penne pasta and broccoli back into the skillet with the Alfredo sauce. Toss gently to coat everything evenly. Finally, stir in the sliced Cajun-spiced chicken. Let everything heat through for another 2-3 minutes, allowing the flavors to meld perfectly.

Step 6: Garnish and Serve

Transfer the Cajun Chicken Alfredo with Broccoli & Penne to serving plates or a large serving dish. Sprinkle freshly chopped parsley over the top for a pop of color and fresh flavor. Serve immediately while warm and creamy.

Easy Ingredient Swaps

Chicken: Substitute with turkey breast or shrimp for a different protein twist.
Cajun Seasoning: Use Creole seasoning or a simple mix of smoked paprika and chili powder.
Penne Pasta: Swap with fusilli, rigatoni, or even gluten-free pasta.
Broccoli: Use asparagus tips, green beans, or spinach for variety.
Heavy Cream: For a lighter option, use half-and-half or a mix of milk and cream cheese.
Parmesan Cheese: Try Pecorino Romano or Grana Padano for a similar sharpness.

Chef’s Rationale

This recipe is designed to balance bold flavors with creamy textures. The Cajun seasoning is the star, infusing the chicken with a complex mix of heat and spice, which contrasts beautifully with the silky Alfredo sauce. The broccoli adds freshness and a slight crunch to keep the dish from feeling too heavy.

Using penne pasta helps to catch and hold the sauce better than flatter pasta shapes.
Cooking the broccoli alongside the pasta saves time and locks in its vibrant green color.
Searing the chicken first allows for caramelization, enhancing the depth of flavor.
Finishing the dish in the skillet ensures the sauce clings perfectly to every component.

Storage Pro Tips

Store any leftovers in an airtight container and refrigerate for up to 3 days. To reheat, warm gently in a skillet over low heat, adding a splash of milk or cream to loosen the sauce if it has thickened. Avoid microwaving directly as it can cause the sauce to separate. For longer storage, freeze the dish without the broccoli, as it tends to lose texture when frozen; add fresh broccoli when reheating.

Your Questions, Answered

Can I make this recipe dairy-free?

Yes! Substitute the heavy cream with full-fat coconut milk or a dairy-free cream alternative, and use a vegan Parmesan cheese or nutritional yeast to keep the cheesy flavor.

Is it possible to prep this recipe ahead of time?

Absolutely. You can season and cook the chicken in advance and store it separately. Cook the pasta and broccoli ahead as well, then assemble and warm everything together just before serving.

How spicy is the Cajun seasoning in this dish?

The spice level is moderate and can be adjusted by choosing a milder or hotter Cajun blend. If you prefer less heat, reduce the seasoning amount or opt for a milder spice mix.

Can I use a different cooking method for the chicken?

Yes, grilling or baking the chicken works well too. If you want a quicker option, try the Air Fryer Chicken And Broccoli method, which adds a nice crisp texture and is incredibly convenient.

Weekend Projects

Instant Pot Chicken Alfredo Tortellini Soup – a delicious twist if you want a cozy, soup version of creamy chicken Alfredo.
Air Fryer Chicken And Broccoli – try this for a quick, healthy side or protein to add to your pasta dishes.
Homemade Cajun seasoning blend – mix your own spices to customize heat levels and flavor profiles.
Fresh pasta making – experiment with making your own penne or fettuccine for an elevated experience.

Serve & Enjoy

Serve your Cajun Chicken Alfredo with Broccoli & Penne hot from the skillet, garnished with fresh parsley and extra grated Parmesan if desired. Pair it with a crisp green salad or garlic bread for a complete meal that satisfies every craving. This dish offers the perfect harmony of spice, creaminess, and freshness, guaranteed to delight everyone at the table. Whether it’s a busy weeknight or a special occasion, this recipe is sure to become a beloved classic in your kitchen.

Enjoy every bite!

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