Tex-Mex Meaty Mac n Cheese Casserole
If you’re looking for a dish that combines comforting mac and cheese with the bold flavors of Tex-Mex, then you’re in for a treat! This Tex-Mex Meaty Mac n Cheese Casserole is a hearty, satisfying meal that’s perfect for busy weeknights or casual gatherings. Packed with lean ground turkey, zesty salsa, and gooey cheese, it’s a dish that the whole family will love. Plus, it’s simple to make and even easier to devour. Let’s dive into this delicious recipe!
Why I Love This Recipe
There’s something truly special about a casserole that brings together different flavors and textures in one dish. The Tex-Mex Meaty Mac n Cheese Casserole is not only comforting but also full of vibrant spices that elevate the traditional mac and cheese. It’s a one-pot meal that’s perfect for meal prepping, and the leftovers are just as tasty. The combination of lean ground turkey, whole-grain pasta, and fresh cilantro makes this dish a healthy yet indulgent option that you can feel good about serving.
Ingredient Checklist
To create this scrumptious Tex-Mex Meaty Mac n Cheese Casserole, you will need the following ingredients:
- 1 pound lean ground turkey
- 1 small yellow onion, peeled and diced
- 1 1/2 teaspoons kosher or sea salt
- 6 ounces whole-grain macaroni (dry) or penne, or 3 cups cooked
- 16 ounces salsa jar, no sugar added
- 2 teaspoons chili powder
- 2 teaspoons cumin
- 1/2 teaspoon black pepper
- 1/4 cup cilantro, freshly chopped, plus more for garnish
- 2 cups Mexican-style cheese, shredded, low-fat (optional cheddar)
Must-Have Equipment
To make your cooking experience smooth and enjoyable, gather the following equipment:
- Large skillet – for browning the turkey and sautéing the onions.
- Large pot – for boiling the pasta.
- Baking dish – to assemble and bake the casserole.
- Wooden spoon – for mixing ingredients.
- Measuring cups and spoons – for accurate ingredient measurement.
Directions: Tex-Mex Meaty Mac n Cheese Casserole

Step 1: Cook the Pasta
Begin by cooking the whole-grain macaroni or penne according to package instructions until al dente. Drain and set aside.
Step 2: Brown the Turkey
In a large skillet, heat a splash of oil over medium heat. Add the diced yellow onion and sauté until it becomes translucent, about 3-4 minutes. Add the ground turkey to the skillet and cook until browned and cooked through, breaking it apart with a wooden spoon as it cooks.
Step 3: Season the Mixture
Once the turkey is browned, stir in the kosher salt, chili powder, cumin, and black pepper. Mix well to ensure the turkey is evenly coated with the spices.
Step 4: Add Salsa
Pour the salsa into the skillet with the turkey mixture. Stir to combine and let it simmer for about 5 minutes, allowing the flavors to meld together.
Step 5: Combine with Pasta
In a large mixing bowl, combine the cooked pasta, turkey and salsa mixture, and chopped cilantro. Mix until everything is evenly distributed.
Step 6: Add Cheese
Fold in the shredded Mexican-style cheese, reserving some for topping the casserole.
Step 7: Assemble the Casserole
Preheat your oven to 350°F (175°C). Transfer the pasta mixture into a greased baking dish. Sprinkle the reserved cheese on top.
Step 8: Bake
Bake in the preheated oven for 25-30 minutes, or until the cheese is bubbly and slightly golden. Remove from the oven and let it cool for a few minutes.
Step 9: Garnish and Serve
Top with additional chopped cilantro for garnish. Serve warm and enjoy your delicious Tex-Mex Meaty Mac n Cheese Casserole!
Fit It to Your Goals

This Tex-Mex Meaty Mac n Cheese Casserole can be easily adjusted to fit your dietary goals:
- Use whole-grain pasta for added fiber and nutrients.
- Substitute lean ground turkey with lean ground beef or plant-based protein for a different flavor profile.
- Add more vegetables like bell peppers, corn, or zucchini for extra nutrition and flavor.
- Use low-fat cheese or reduce the cheese quantity to lower the calorie count.
Slip-Ups to Skip
When making the Tex-Mex Meaty Mac n Cheese Casserole, keep these common mistakes in mind:
- Don’t overcook the pasta; it should be al dente since it will continue to cook in the oven.
- Be cautious with the salt, especially if your salsa is already salted. Adjust to taste.
- Ensure to let the casserole cool for a few minutes before serving to avoid burns from hot cheese.
- Don’t skip the fresh cilantro; it adds a burst of freshness that complements the dish beautifully.
Best Ways to Store
To keep your Tex-Mex Meaty Mac n Cheese Casserole fresh, consider the following storage tips:
- Store leftovers in an airtight container in the refrigerator for up to 3-4 days.
- To freeze, portion the casserole into freezer-safe containers and freeze for up to 3 months.
- When reheating, add a splash of milk to keep it creamy, and cover with foil to prevent drying out.
Questions People Ask
Can I make this casserole ahead of time?
Absolutely! You can prepare the casserole up to the baking step, cover it, and store it in the refrigerator for up to 24 hours before baking. Just add a few extra minutes to the baking time if it’s coming straight from the fridge.
What can I serve with this casserole?
This casserole is a meal in itself, but you can serve it with a simple side salad or some steamed vegetables for a complete dinner.
Can I use a different type of meat?
Yes! Feel free to use ground beef, chicken, or even a plant-based meat substitute to suit your dietary preferences.
Is this casserole spicy?
The spice level will depend on the salsa you use. Choose a mild salsa for a milder dish or a hot salsa for a kick. You can also adjust the chili powder to your preference.
If you’re looking for more healthy-ish recipes to enjoy, check out these favorites:
That’s a Wrap
This Tex-Mex Meaty Mac n Cheese Casserole is a delightful fusion of flavors that satisfies cravings while still being mindful of health. It’s perfect for busy weeknights, potlucks, or simply when you want a comforting meal that feeds a crowd. With its ease of preparation and adaptable ingredients, it’s destined to become a favorite in your recipe repertoire. So why not gather your ingredients and get cooking? Your taste buds will thank you!

Tex-Mex Meaty Mac n Cheese Casserole
Ingredients
- 1 pound lean ground turkey
- 1 small yellow onion peeled and diced
- 1 1/2 teaspoons kosher or sea salt
- 6 ounces whole-grain macaroni or penne (dry) or 3 cups cooked
- 16 ounces salsa no sugar added
- 2 teaspoons chili powder
- 2 teaspoons cumin
- 1/2 teaspoon black pepper
- 1/4 cup cilantro freshly chopped, plus more for garnish
- 2 cups Mexican-style cheese shredded, low-fat (optional cheddar)
Instructions
Directions: Tex-Mex Meaty Mac n Cheese Casserole
- Begin by cooking the whole-grain macaroni or penne according to package instructions until al dente. Drain and set aside.
- In a large skillet, heat a splash of oil over medium heat. Add the diced yellow onion and sauté until translucent, about 3-4 minutes. Add the ground turkey and cook until browned and cooked through, breaking it apart with a wooden spoon as it cooks.
- Stir in the kosher salt, chili powder, cumin, and black pepper. Mix well to evenly coat the turkey with spices.
- Pour the salsa into the skillet with the turkey mixture. Stir to combine and let it simmer for about 5 minutes to meld flavors.
- In a large mixing bowl, combine the cooked pasta, turkey and salsa mixture, and chopped cilantro. Mix until evenly distributed.
- Fold in the shredded Mexican-style cheese, reserving some for topping the casserole.
- Preheat oven to 350°F (175°C). Transfer the pasta mixture into a greased baking dish. Sprinkle reserved cheese on top.
- Bake for 25-30 minutes, until cheese is bubbly and slightly golden. Remove from oven and let cool for a few minutes.
- Top with additional chopped cilantro for garnish. Serve warm and enjoy your Tex-Mex Meaty Mac n Cheese Casserole!
Equipment
- Large Skillet
- Large Pot
- Baking Dish
- Wooden Spoon
- Measuring Cups and Spoons
Notes
- Use whole-grain pasta for added fiber and nutrients.
- Substitute lean ground turkey with ground beef or plant-based protein for variety.
- Store leftovers in an airtight container in the fridge for 3-4 days or freeze for up to 3 months.

