If you’re searching for a comforting, creamy, and utterly indulgent pasta bake, look no further than Three Cheese Chicken Tetrazzini. This recipe combines tender chicken, a luscious three-cheese sauce, earthy mushrooms, and perfectly cooked spaghetti in a harmonious dish that’s perfect for weeknight dinners or special occasions. Imagine a golden, bubbly top crust giving way to a velvety, cheesy filling that hugs every strand of pasta — this is the kind of meal that feels like a warm hug on a plate.

Why This Recipe is a Keeper

What sets this Three Cheese Chicken Tetrazzini apart from the rest? First, it’s the balance of three distinct cheeses — parmesan, cream cheese, and mozzarella — each bringing a unique texture and flavor. The parmesan adds a sharp, nutty undertone, cream cheese provides creaminess and body, while mozzarella gives that irresistible gooey stretch. The chicken is cooked just right, juicy and tender, and the mushrooms lend an earthy depth that rounds out the dish beautifully.

This recipe is straightforward, uses pantry staples, and comes together in under an hour, making it perfect for busy weeknights or casual entertaining. Plus, it’s endlessly adaptable, so you can swap ingredients to suit your pantry or preferences. If you love dishes like Easy Baked Chicken Parmesan or creamy pasta bakes, this Three Cheese Chicken Tetrazzini will quickly become a favorite go-to.

Ingredient Checklist

12 ounces uncooked spaghetti – the perfect base to soak up the creamy sauce
1 tablespoon olive oil – for sautéing and adding flavor
3 tablespoons butter, divided – enriches both the chicken and the sauce
1/2 medium onion, chopped – adds sweetness and depth
2 uncooked chicken breasts, cut into 1″ pieces – the hearty protein star
Salt & pepper, to taste – essential seasoning
4 cloves garlic, minced – aromatic and flavorful
1/4 teaspoon Italian seasoning – for a subtle herby note
7 ounces cremini or white mushrooms, sliced – earthy and meaty texture
3/4 cup chicken broth – adds moisture and savory richness
1 cup heavy/whipping cream – makes the sauce luxuriously creamy
8 ounces cream cheese, softened – smooth and tangy
1 cup freshly grated parmesan cheese – sharp and nutty
1 cup shredded mozzarella cheese – melty and stretchy

Essential Tools for Success

Large pot: To boil the spaghetti perfectly al dente.
Large skillet or sauté pan: For cooking the chicken, onions, garlic, and mushrooms.
Measuring cups and spoons: To ensure ingredient accuracy, especially for the cheeses and liquid.
Mixing bowl: To combine the cheeses and cream before adding to the skillet.
Baking dish (9×13 inch recommended): For assembling and baking the casserole.
Wooden spoon or spatula: For stirring and ensuring everything is evenly mixed.

From Start to Finish: Three Cheese Chicken Tetrazzini

Step 1: Cook the Spaghetti

Bring a large pot of salted water to a boil. Add the spaghetti and cook until just al dente, about 8-9 minutes. Drain and set aside. Toss with 1 tablespoon olive oil to prevent sticking.

Step 2: Sauté the Aromatics and Chicken

In a large skillet, melt 1 tablespoon of butter over medium heat. Add the chopped onion and sauté until translucent, about 3 minutes. Add the minced garlic and cook for another 30 seconds until fragrant. Increase the heat to medium-high, add the chicken pieces, season with salt, pepper, and Italian seasoning, and cook until golden and cooked through, about 5-7 minutes. Remove chicken and set aside.

Step 3: Cook the Mushrooms

In the same skillet, melt 1 tablespoon butter. Add the sliced mushrooms and sauté until they release their moisture and start to brown, about 6 minutes. Season lightly with salt and pepper.

Step 4: Prepare the Creamy Cheese Sauce

Add the chicken broth and heavy cream to the mushrooms. Bring to a gentle simmer, scraping up any browned bits on the pan. Reduce heat to low and add the softened cream cheese, stirring until smooth and creamy. Mix in the grated parmesan and half of the shredded mozzarella cheese until melted and fully incorporated.

Step 5: Combine All Ingredients

Return the cooked chicken to the skillet and stir to combine. Add the cooked spaghetti and toss gently to coat every strand in that luscious sauce.

Step 6: Assemble and Bake

Preheat your oven to 350°F (175°C). Transfer the pasta mixture into a greased 9×13 baking dish. Sprinkle the remaining mozzarella cheese evenly on top. Dot the last tablespoon of butter over the cheese to promote browning. Bake uncovered for 20-25 minutes or until the top is golden and bubbly.

Step 7: Serve and Enjoy

Let the Three Cheese Chicken Tetrazzini rest for about 5 minutes before serving. This allows the sauce to thicken slightly for perfect slicing and serving.

Variations for Dietary Needs

Gluten-Free: Use gluten-free spaghetti to make this dish accessible for those with gluten sensitivities.
Lower Fat: Substitute half-and-half for heavy cream and use reduced-fat cream cheese and mozzarella.
Vegetarian: Replace chicken with sautéed zucchini, bell peppers, or extra mushrooms for a hearty vegetarian version.
Dairy-Free: Use dairy-free cream cheese, plant-based milk (like cashew cream), and vegan cheese alternatives.

Errors to Dodge

Overcooking the pasta: Spaghetti will continue cooking in the oven, so undercook it slightly to avoid mushiness.
Not softening the cream cheese: If it’s too cold, it can create lumps in the sauce.
Skipping seasoning: Salt and pepper bring out the best in every ingredient—don’t forget to taste and adjust.
Uneven cooking of chicken pieces: Cut chicken into similar sizes for consistent cooking.

Cooling, Storing & Rewarming

After baking, allow the Three Cheese Chicken Tetrazzini to cool to room temperature, then store leftovers in an airtight container in the refrigerator for up to 3 days. When reheating, cover with foil and warm in a 350°F oven until heated through, about 15-20 minutes. You can also microwave individual portions; just add a splash of broth or cream to keep it creamy and prevent drying out.

Your Questions, Answered

Can I use rotisserie chicken instead of raw chicken breasts?

Absolutely! Using pre-cooked rotisserie chicken is a great shortcut. Simply shred the chicken and add it to the sauce in Step 5 instead of cooking raw chicken. This will save time and still deliver fantastic flavor.

Is it better to use fresh or dried pasta?

For this recipe, dried spaghetti works best as it holds up well during baking and absorbs the sauce nicely. Fresh pasta tends to be more delicate and may become mushy in the oven.

Can I freeze Three Cheese Chicken Tetrazzini?

Yes, you can freeze the unbaked casserole. Assemble it as instructed, cover tightly with foil or plastic wrap, and freeze for up to 2 months. When ready to bake, thaw overnight in the refrigerator and then bake as directed, adding a few extra minutes if needed.

What can I serve alongside this dish?

A crisp green salad or steamed vegetables like broccoli or green beans complement the richness of this dish perfectly. For another chicken favorite with veggies, try this Skillet Chicken Alfredo Broccoli With Spinach for a quick and satisfying side or alternate meal.

What to Make After This

Easy Baked Chicken Parmesan – a classic Italian-inspired chicken dish with crispy breaded chicken and melty cheese.
Skillet Chicken Alfredo Broccoli With Spinach – a creamy, cheesy skillet meal packed with greens and tender chicken.
Garlic Bread – to soak up any leftover sauce from your Tetrazzini.
Simple Caesar Salad – crisp romaine with a tangy dressing balances the creamy pasta.

In Closing

Three Cheese Chicken Tetrazzini is more than just a pasta bake — it’s a celebration of comfort food done right. The combination of tender chicken, mushrooms, and a rich trio of cheeses creates a dish that pleases every craving for warmth and indulgence. Whether you’re feeding a family or prepping for a cozy night in, this recipe delivers on flavor, texture, and ease. Once you’ve mastered this classic, you’ll find yourself turning to it again and again for those moments when only creamy, cheesy, satisfying pasta will do.

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