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Tuscan Spinach Artichoke Chicken Bake

This Tuscan Spinach Artichoke Chicken Bake is creamy, cheesy, and packed with vibrant Mediterranean flavors—perfect for a comforting weeknight dinner!
Prep Time15 minutes
Cook Time25 minutes
Total Time40 minutes
Course: Main Course
Cuisine: Italian, Mediterranean, Tuscan
Keyword: Artichoke, Baked, Cheesy, Chicken, Easy, Quick, Spinach
Servings: 4 servings

Ingredients

  • 4 boneless, skinless chicken breasts
  • 14 ounces artichoke hearts canned, drained and chopped
  • 1 cup fresh spinach chopped
  • 1 cup cream cheese softened
  • 1/2 cup sour cream
  • 1 cup shredded mozzarella cheese
  • 1/2 cup grated Parmesan cheese
  • 2 cloves garlic minced
  • 1 tablespoon olive oil
  • 1 teaspoon dried oregano
  • 1 teaspoon dried basil
  • salt and pepper to taste

Instructions

Prepare the Oven and Chicken

  • Preheat your oven to 375°F (190°C). Pat the chicken breasts dry with paper towels, then season both sides generously with salt, pepper, dried oregano, and dried basil.

Sear the Chicken

  • In a large oven-safe skillet or frying pan, heat the olive oil over medium-high heat. Add the chicken breasts and sear for 3-4 minutes on each side until golden brown. Remove the chicken from the pan and set aside.

Prepare the Creamy Spinach Artichoke Mixture

  • In a mixing bowl, combine softened cream cheese, sour cream, minced garlic, chopped spinach, and chopped artichoke hearts. Stir until well incorporated. Fold in half of the shredded mozzarella and all the grated Parmesan cheese.

Assemble the Bake

  • Return the seared chicken breasts to the skillet or transfer to a baking dish. Spoon the spinach artichoke cream cheese mixture evenly over each chicken breast. Sprinkle the remaining mozzarella cheese on top.

Bake Until Perfect

  • Bake in the preheated oven for 20-25 minutes, until the chicken is cooked through and the cheese is melted and slightly browned. The chicken’s internal temperature should reach 165°F (74°C).

Serve and Enjoy

  • Let the dish rest for a few minutes before serving. Serve with your favorite sides such as roasted vegetables, quinoa, or a crisp green salad.

Equipment

  • Oven
  • Large oven-safe skillet
  • Mixing Bowl
  • Frying pan
  • Baking Dish

Notes

  • Use Room Temperature Cream Cheese: Softened cream cheese blends more smoothly creating a creamier topping.
  • Don’t Skip Searing: Browning the chicken first adds flavor and keeps it juicy during baking.
  • Fresh vs. Frozen Spinach: Thaw and squeeze out frozen spinach to avoid watery bake.
  • Customize Cheese Options: Swap mozzarella for provolone or fontina for different flavors.
  • Make Ahead: Prepare the creamy mixture and chicken in advance, then assemble and bake when ready.