Preheat the oven to 350°F and lightly spray a 9×13-inch baking dish with nonstick spray.
Bring a large pot of salted water to a boil; cook the campanelle according to package directions until al dente, then drain and set aside.
In a 12-inch skillet over medium-high heat, cook the ground beef until no pink remains, breaking it up with a masher or spatula; drain excess grease.
Add the taco seasoning, 3/4 cup water, and the undrained can of Rotel to the cooked beef; simmer over medium heat about 5 minutes, stirring occasionally.
Stir in the jar of salsa con queso, heavy cream, chili powder, onion powder, and garlic powder until combined and heated through.
Fold the cooked pasta and 1 cup of the shredded cheddar into the beef mixture; taste and season with salt and black pepper if desired.
Transfer the mixture to the prepared 9×13 baking dish, sprinkle the remaining 1 cup shredded cheddar evenly over the top, and bake for 20 minutes.
Remove from the oven, top with the crushed Doritos, then return to the oven and bake an additional 5–10 minutes until bubbly.