Preheat the oven to 400°F (200°C) and line a baking sheet with foil or parchment if desired for easier cleanup.
In a small bowl, whisk together the lime juice, olive oil, chili powder, garlic powder, onion powder, salt, and black pepper until evenly combined.
Place the salmon fillets skin-side down on the prepared baking sheet, leaving a little space between each piece.
Brush or spoon the lime-spice mixture evenly over the top of each fillet so they are well coated.
Bake the salmon in the preheated oven for 10 to 15 minutes, or until the fish flakes easily with a fork and reaches your desired doneness.
Remove from the oven and let rest for a minute, then serve with your preferred sides.