Pour the buttermilk into a large bowl. Add a pinch of salt and pepper, then submerge the chicken tenders. Cover and refrigerate for at least 30 minutes, or up to 2 hours to tenderize.
In another bowl, whisk together the flour, paprika, cayenne pepper, garlic powder, onion powder, salt, and pepper to prepare the seasoned flour coating.
Pour vegetable oil into a deep skillet to about 1 to 1.5 inches deep and heat over medium-high heat to 350°F (175°C).
Remove chicken tenders from the buttermilk, letting excess drip off. Dredge each tender in the seasoned flour mixture, pressing lightly to adhere. Shake off excess flour.
Fry tenders in hot oil for about 3-4 minutes per side until golden and cooked through (internal temperature 165°F/74°C). Transfer to a wire rack to drain.
While frying, combine honey, hot sauce, apple cider vinegar, and cayenne pepper in a small saucepan over low heat. Stir until warm, smooth and slightly thickened, then remove from heat.
Place fried tenders in a large bowl and drizzle the hot honey sauce over them. Toss gently to coat. Sprinkle with chopped parsley to garnish.