Preheat the oven to 400°F (200°C). Line a rimmed baking sheet with foil and set a wire rack on top.
In a shallow bowl, whisk together the eggs, Dijon mustard, honey, 1/4 teaspoon cayenne, and salt and black pepper to taste until smooth.
In a second shallow bowl, combine the panko, 1 teaspoon salt, 3/4 teaspoon ground black pepper, smoked paprika, remaining 1/4 teaspoon cayenne, and garlic powder; whisk to mix evenly.
Place the flour in a third shallow bowl.
Dredge each chicken tenderloin first in the flour, shaking off excess, then dip into the egg-honey-mustard mixture, and finally press into the panko mixture to coat evenly.
Arrange the breaded tenders on the wire rack with space between pieces. Lightly coat the tops with cooking spray.
Bake for 15–18 minutes at 400°F until the coating is golden and the internal temperature reaches 165°F (74°C).