Preheat the oven to 375°F (190°C).
In a small bowl, combine 1/4 cup extra virgin olive oil, 1 tsp Italian seasoning, 1 tsp garlic powder OR 2 garlic cloves, minced, 1/4 tsp fine sea salt, and 1/4 tsp freshly ground black pepper. Stir to combine and set aside to let the flavors infuse while you prepare the bread.
Cut or tear the 12 oz crusty bread loaf into about 3/4" cubes (keeping the crusts on is fine). Transfer the bread pieces to a large mixing bowl.
Drizzle the seasoned olive oil evenly over the bread pieces and gently toss until all pieces are lightly and evenly coated.
Spread the coated bread pieces in a single layer on a rimmed baking sheet.
Bake at 375°F for 15–20 minutes, stirring once halfway through, until the croutons are crisp and fully dried out. (Baking time will vary with cube size and bread type.)
Remove the baking sheet from the oven and let the croutons cool to room temperature on the sheet so they become fully crisp.
Transfer cooled croutons to a large zip-top bag or an airtight container and store at room temperature for up to 2 weeks.