Preheat the oven to 325°F. Butter a springform pan.
In a bowl (or food processor), combine the 1/4 cup finely chopped pecans, 1/4 cup finely chopped almonds, 1/4 cup finely chopped walnuts, 3/4 cup finely chopped vanilla wafers, and 2 tablespoons melted butter. Stir or pulse until the dry ingredients are evenly moistened.
Press the mixture firmly into the buttered springform pan, spreading it over the bottom and about 1½ inches up the sides. Set the prepared crust aside.
Fit a mixer with the paddle or beaters and keep it on the low speed for all mixing steps. Add 1 1/2 pounds cream cheese to the mixer bowl and beat on low until light and fluffy.
With the mixer running on low, add 1 1/3 cups sugar a little at a time and continue beating until the mixture is smooth and creamy. Stop occasionally to scrape the bowl sides as needed.
Add the 5 eggs one at a time, beating on low and mixing each egg in completely before adding the next. Mix only until each egg is incorporated.
Add 1/4 cup flour, 2 teaspoons lemon juice, and 2 teaspoons vanilla; mix on low until combined.
Add 16 ounces sour cream and beat on low until the batter is smooth and evenly combined.
Pour the cream cheese filling into the prepared crust and smooth the top. Place the pan on the middle oven rack and bake at 325°F for 1 hour and 15 minutes.
When baking is finished, turn off the oven, prop the oven door open about 1 inch, and let the cheesecake sit in the oven for 1 hour.
Remove the cheesecake from the oven, allow it to cool until it is safe to handle and not hot, then refrigerate for 24 hours before serving.