Use high-quality meat. I prefer organic beef because it has no additives.
Also, use lean beef for this, or you will get too much grease. If you are using anything below 80/20, you should drain the grease from the pot before you start cooking it.
Do not skip the browning process. This will keep the juices and seasonings inside where they belong.
Do not pre-cook your pasta, or you may end up with soggy noodles.
To keep the pasta from sticking, scrape any beef off the bottom of the pot.
Also to keep it from sticking, add the pasta last and do not stir. Just push it down slightly so it is in the liquid.