Preheat oven to 350°F. Line a 9x13-inch pan with foil and spray the foil with cooking spray.
In the bowl of a stand mixer fitted with the paddle attachment (or using a handheld mixer), combine the 1 box brownie mix (19.5 oz), 1 stick softened butter, and 1 egg. Beat until all dry mix is incorporated and the batter is thick.
Press the brownie batter evenly into the bottom of the prepared pan to form a uniform crust.
Evenly sprinkle the chopped 8 Reese’s Peanut Butter Cups, the 1/2 cup peanut butter chips, and the 1 cup milk chocolate chips over the brownie crust.
Pour the entire 14-oz can of sweetened condensed milk evenly over the candy pieces, covering as much surface as possible.
Bake in the preheated oven for 28–30 minutes, until the edges are set and begin to brown and the center is no longer jiggly.
Remove from the oven and let cool completely in the pan on a rack. Once fully cooled, lift the bars from the pan using the foil and slice into desired-sized bars.