Line a baking dish (or multiple 8×8-inch glass baking dishes) with heavy-duty foil, leaving an overhang on the sides so you can lift the fudge out later. Choose dish(es) large enough to hold the entire mixture from the 11 lb container Pillsbury vanilla frosting and 2 3/4 cups Biscoff Spread.
Place the 11 lb container Pillsbury vanilla frosting and 2 3/4 cups Biscoff Spread into a very large microwave-safe bowl. If they will not fit in one bowl, work in batches (see step 3).
Microwave on High in 30–60 second intervals, removing and stirring thoroughly after each interval, until the frosting and Biscoff are fully melted and the mixture is smooth and uniform. If working in batches, microwave and stir each batch until melted.
If you used batches, combine all melted batches into one large bowl and stir until the texture and color are uniform.
Immediately pour the combined mixture into the foil-lined baking dish(es) and spread evenly with a spatula.
Refrigerate until firm (about 1–2 hours or until set).
Use the foil overhang to lift the fudge from the dish, remove the foil, and cut into pieces.