In a large mixing bowl, combine the ground beef, Italian seasoned bread crumbs, sea salt, black pepper, all-purpose flour, and egg. Mix until just combined, being careful not to overwork the meat.
Using your hands, shape the mixture into meatballs about 1-2 inches in diameter. Place them on a plate or baking sheet as you go.
In a large skillet, heat the olive oil over medium heat. Once hot, add the meatballs in batches, being careful not to overcrowd the pan. Cook until they are browned on all sides, about 5-7 minutes.
Once the meatballs are browned, pour in the pasta sauce. Reduce the heat to low and let it simmer for about 15-20 minutes, allowing the flavors to meld beautifully.
While the sauce is simmering, bring a large pot of salted water to a boil. Add the spaghetti and cook according to package instructions until al dente. Drain the pasta, reserving a bit of the cooking water.
Toss the cooked spaghetti with the meatballs and sauce, adding a splash of the reserved pasta water if needed to loosen the sauce. Serve hot, topped with grated Parmesan cheese.