Wash zucchini thoroughly and slice into 1/4-inch thick rounds. Cut larger rounds in half if desired for smaller medallions.
Pat zucchini slices dry with paper towels to remove excess moisture.
In one shallow bowl, whisk the eggs until well beaten.
In a second bowl, combine breadcrumbs, grated Parmesan cheese, garlic powder, onion powder, Italian seasoning, salt, and pepper. Mix well.
Dip each zucchini slice into the beaten eggs, letting excess drip off, then coat thoroughly in the breadcrumb mixture. Press crumbs onto zucchini to stick well. Set aside on a plate or tray.
Preheat air fryer to 400°F (200°C) for 3-5 minutes. Lightly spray air fryer basket with cooking spray to prevent sticking.
Place breaded zucchini medallions in a single layer in the air fryer basket, avoiding overlap. Lightly spray tops with cooking spray.
Cook for 8-10 minutes, flipping halfway through, until golden brown and crispy. Adjust time as needed based on air fryer and zucchini thickness.
Remove from air fryer and serve immediately with marinara sauce, ranch dressing, or yogurt dip. Enjoy!